< 年度盘点 – 质谱流式国内已发表文献汇总

        随着生命科学的不断发展及对单细胞分析手段越来越高的需求,传统的荧光流式细胞技术已不能满足科学家们的需要。Fluidigm公司独有的质谱流式技术(Mass Cytometry)应运而生。它通过对传统流式技术和质谱技术的整合,是目前单细胞多参数分析中最先进的技术之一。它继承了传统流式细胞仪的高速分析的特点,又具有质谱检测的高分辨能力,更高效、更易用,同时能够更加深入地进行细胞表型、信号通路和功能的全面研究,是流式细胞技术一个新的发展方向。
 
        随着质谱流式技术的不断推广,越来越多国内的科研、临床及药物研发的工作者们将他们敏锐的目光投向了这一先进的技术。在一系列国内科研项目或国际合作项目中,国内科学家基于质谱流式技术取得了大量研究成果,涉及肿瘤、免疫、转化医学、干细胞、药理研究等诸多领域,质谱流式技术以其在研究深度、广度和数据全面性等方面的卓越性能,为研究者们提供了良好的实验技术平台,领跑流式发展的最前沿。
  
        以下为大家摘取截止2020年2月部分国内学者基于质谱流式技术发表的文献列表(按发表时间顺序排列),欢迎大家查阅。



标题 刊物 发表时间 研究内容
High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas Frontiers in Oncology Feb 04, 2020 弥漫性星形细胞瘤(DA)的免疫微环境特征研究
A Carrier Strategy for Mass Cytometry Analysis of Small Numbers of Cells Methods Mol Biol Jan, 2020 Cytof技术检测方法研究
Phenotype molding of T cells in colorectal cancer by single-cell analysis Int J Cancer Jan, 2020 研究大肠癌中T细胞表型变化
A comparison framework and guideline of clustering methods for mass cytometry data Genome Biol Dec, 2019 质谱流式数据聚类分析方法比较
High-dimensional single-cell proteomics analysis reveals the landscape of immune cells and stem-like cells in renal tumors. J Clin Lab Anal Dec, 2019 不同类型肾肿瘤免疫细胞亚群分析
A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation. Blood Adv Dec, 2019 脐带血移植恢复期,NK细胞多样性及其对随后复发的风险预测
Application value of CyTOF 2 mass cytometer technology at single-cell level in human gastric cancer cells Exp Cell Res. Nov, 2019 CyTOF在胃癌研究中的应用价值
Glutathione Might Attenuate Cadmium-Induced Liver Oxidative Stress and Hepatic Stellate Cell Activation Biol Trace Elem Res. Oct, 2019 镉诱导的肝氧化应激和肝星状细胞活化
Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. Cell Mol Immunol Oct, 2019 研究IL-38在过敏性哮喘中的抗炎机制
Single-cell mass cytometry reveals in vivo immunological response to surgical biomaterials Applied Materials Sep, 2019 应用质谱流式技术研究生物材料植入对免疫系统的影响
A Mass-Ratiometry-Based CD45 Barcoding Method for Mass Cytometry Detection SLAS Technol Aug, 2019 Cytof细胞Barcode方法研究
Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury: a high-dimensional analysis Stem Cell Res Ther.  Aug, 2019 MSCs肝损伤过程中的免疫调节作用
The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer. Int J Radiat Oncol Biol Phys. Aug, 2019 RhoB信号通路与结直肠癌耐受放疗机制研究
Immunocyte Profiling Using Single-Cell Mass Cytometry Reveals EpCAM+ CD4+ T Cells Abnormal in Colon Cancer Front Immunol. Jul, 2019 研究结直肠癌患者PBMC的表型变化和免疫治疗靶点的表达
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas Gut Jun, 2019 多组学HCC免疫微环境研究
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1 Gastroenterology. May, 2019 小鼠肝肿瘤对MET抑制剂耐药机制研究
Lymphocyte mass cytometry identifies a CD3-CD4+ cell subset with a potential role in psoriasis. JCI Insight Mar, 2019 银屑病患者PBMC的免疫细胞亚群和信号通路分析
Reduced CD27-IgD- B Cells in Blood and Raised CD27-IgD- B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease. Front Immunol. Mar, 2019 研究炎症性肠病(IBD)的肠内B细胞募集
Ratiometric Barcoding for Mass Cytometry. Anal Chem. Sep, 2018 质谱流式技术barcoding方法
Octaarginine-modified gold nanoparticles enhance the radiosensitivity of human colorectal cancer cell line LS180 to megavoltage radiation. Int J Nanomedicine.  Jun, 2018 纳米材料促进结直肠癌细胞系放射敏感度机制研究
Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia J Transl Med Feb, 2018 阿帕替尼抗白血病机制研究
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. Jul, 2017 TAZ在 TH17和Treg分化过程中的作用
Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer. Mol Cancer. Mar, 2017 PXR对奥沙利铂的转运作用及其引发的耐药性机制研究
Single cell proteomics in biomedicine: High-dimensional data acquisition, visualization, and analysis. Proteomics. Feb, 2017 数据分析方法研究

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